An anaplastic lymphoma kinase (ALK) immunohistochemistry negative but fluorescence in situ hybridization (FISH) positive lung adenocarcinoma is resistant to Crizotinib

INTRODUCTION: Oncogenic fusion of anaplastic lymphoma kinase (ALK) with echinoderm microtubule-like (EML) protein or other partner genes occurs in 3–6% of lung adenocarcinomas. Although fluorescence in situ hybridization (FISH) is the gold standard for detecting ALK gene rearrangement that gives ris...

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Detalhes bibliográficos
Publicado no:J Thorac Oncol
Main Authors: Shi, Ruoshi, Varella-Garcia, Marileila, Li, Ming, Ludkovski, Olga, Danesh, Arnavaz, Christine, Ng, Pham, Nhu-An, Pugh, Trevor, Shepherd, Frances A., Tsao, Ming-Sound
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573599/
https://ncbi.nlm.nih.gov/pubmed/27613526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2016.08.139
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