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Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface
Drug discovery efforts against the pathogen Mycobacterium tuberculosis (Mtb) have been advanced through phenotypic screens of extensive compound libraries. Such a screen revealed sulfolane 1 and indoline-5-sulfonamides 2 and 3 as potent inhibitors of mycobacterial growth. Optimization in the sulfola...
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出版年: | Sci Rep |
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主要な著者: | , , , , , , , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
Nature Publishing Group UK
2017
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5573416/ https://ncbi.nlm.nih.gov/pubmed/28842600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09642-y |
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