Treatment patterns, efficacy and toxicity of regorafenib in gastrointestinal stromal tumour patients

Regorafenib was approved as third-line therapy for advanced Gastrointestinal Stromal Tumour (GIST) at a starting dose of 160 mg daily 3 weeks on, 1 week off, based on improvement in progression free survival over placebo (4.8 vs. 0.9 months), but the response rate was low at 4.5%. Given the high tox...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Schvartsman, Gustavo, Wagner, Michael J., Amini, Behrang, Zobniw, Chrystia M., Trinh, Van Anh, Barbo, Andrea G., Lin, Heather Y., Wang, Wei-Lien, Conley, Anthony Paul, Ravi, Vinod, Araujo, Dejka M., Zarzour, Maria Alejandra, Benjamin, Robert S., Patel, Shreyaskumar, Somaiah, Neeta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573380/
https://ncbi.nlm.nih.gov/pubmed/28842575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09132-1
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