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Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer

The unique amino acid hypusine is present in only two proteins in eukaryotic cells, eukaryotic translation initiation factor 5A-1 (eIF5A1), and eIF5A2, where it is covalently linked to the lysine-50 residue of these proteins via a post-translational modification coined hypusination. This unique modi...

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Podrobná bibliografie
Vydáno v:Amino Acids
Hlavní autoři: Nakanishi, Shima, Cleveland, John L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573165/
https://ncbi.nlm.nih.gov/pubmed/27357307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-016-2275-3
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