Recent developments in age-related macular degeneration: a review
BACKGROUND: Visual impairment in elderly people is a considerable health problem that significantly affects quality of life of millions worldwide. The magnitude of this issue is becoming more evident with an aging population and an increasing number of older individuals. OBJECTIVE: The objective of...
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| Publicado no: | Clin Interv Aging |
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2017
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5573066/ https://ncbi.nlm.nih.gov/pubmed/28860733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CIA.S143508 |
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pubmed-55730662017-08-31 Recent developments in age-related macular degeneration: a review Al-Zamil, Waseem M Yassin, Sanaa A Clin Interv Aging Review BACKGROUND: Visual impairment in elderly people is a considerable health problem that significantly affects quality of life of millions worldwide. The magnitude of this issue is becoming more evident with an aging population and an increasing number of older individuals. OBJECTIVE: The objective of this article was to review the clinical and pathological aspects of age-related macular degeneration (AMD), diagnostic tools, and therapeutic modalities presently available or underway for both atrophic and wet forms of the disease. METHODS: An online review of the PubMed database was performed, searching for the key words. The search was limited to articles published since 1980 to date. RESULTS: Several risk factors have been linked to AMD, such as age (>60 years), lifestyle (smoking and diet), and family history. Although the pathogenesis of AMD remains unclear, genetic factors have been implicated in the condition. Treatment for atrophic AMD is mainly close observation, coupled with nutritional supplements such as zinc and antioxidants, whereas treatment of wet AMD is based on targeting choroidal neovascular membranes. CONCLUSION: Identification of modifiable risk factors would improve the possibilities of preventing the progression of AMD. The role of anti-vascular endothelial growth factor (anti-VEGF) agents has transformed the therapeutic approach of the potentially blinding disease “wet AMD” into a more favorable outcome. Dove Medical Press 2017-08-22 /pmc/articles/PMC5573066/ /pubmed/28860733 http://dx.doi.org/10.2147/CIA.S143508 Text en © 2017 Al-Zamil and Yassin. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
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Inglês |
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Artigo |
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Review |
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Review Al-Zamil, Waseem M Yassin, Sanaa A Recent developments in age-related macular degeneration: a review |
| description |
BACKGROUND: Visual impairment in elderly people is a considerable health problem that significantly affects quality of life of millions worldwide. The magnitude of this issue is becoming more evident with an aging population and an increasing number of older individuals. OBJECTIVE: The objective of this article was to review the clinical and pathological aspects of age-related macular degeneration (AMD), diagnostic tools, and therapeutic modalities presently available or underway for both atrophic and wet forms of the disease. METHODS: An online review of the PubMed database was performed, searching for the key words. The search was limited to articles published since 1980 to date. RESULTS: Several risk factors have been linked to AMD, such as age (>60 years), lifestyle (smoking and diet), and family history. Although the pathogenesis of AMD remains unclear, genetic factors have been implicated in the condition. Treatment for atrophic AMD is mainly close observation, coupled with nutritional supplements such as zinc and antioxidants, whereas treatment of wet AMD is based on targeting choroidal neovascular membranes. CONCLUSION: Identification of modifiable risk factors would improve the possibilities of preventing the progression of AMD. The role of anti-vascular endothelial growth factor (anti-VEGF) agents has transformed the therapeutic approach of the potentially blinding disease “wet AMD” into a more favorable outcome. |
| author |
Al-Zamil, Waseem M Yassin, Sanaa A |
| author_facet |
Al-Zamil, Waseem M Yassin, Sanaa A |
| author_sort |
Al-Zamil, Waseem M |
| title |
Recent developments in age-related macular degeneration: a review |
| title_short |
Recent developments in age-related macular degeneration: a review |
| title_full |
Recent developments in age-related macular degeneration: a review |
| title_fullStr |
Recent developments in age-related macular degeneration: a review |
| title_full_unstemmed |
Recent developments in age-related macular degeneration: a review |
| title_sort |
recent developments in age-related macular degeneration: a review |
| publisher |
Dove Medical Press |
| container_title |
Clin Interv Aging |
| publishDate |
2017 |
| url |
https://ncbi.nlm.nih.gov/pmc/articles/PMC5573066/ https://ncbi.nlm.nih.gov/pubmed/28860733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CIA.S143508 |
| _version_ |
1819863675736948736 |