Akt activation by Ca(2+)/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells

Hyperactivation of Akt is associated with oncogenic changes in the growth, survival, and chemoresistance of cancer cells. The PI3K/phosphoinositide-dependent kinase (PDK) 1 pathway represents the canonical mechanism for phosphorylation of Akt at its primary activation site, Thr-308. We observed that...

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Publicat a:J Biol Chem
Autors principals: Gocher, Angela M., Azabdaftari, Gissou, Euscher, Lindsey M., Dai, Shuhang, Karacosta, Loukia G., Franke, Thomas F., Edelman, Arthur M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572912/
https://ncbi.nlm.nih.gov/pubmed/28634229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.778464
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