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Differential DNA recognition and glycosylase activity of the native human MutY homolog (hMYH) and recombinant hMYH expressed in bacteria

Human MutY homolog (hMYH), an adenine DNA glycosylase, can effectively remove misincorporated adenines opposite template G or 8-oxoG bases, thereby preventing G:C→T:A transversions. Human cell extracts possess the adenine DNA glycosylase activity of hMYH and can form protein–DNA complexes with both...

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Bibliografski detalji
Glavni autori: Gu, Yesong, Lu, A-Lien
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2001
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC55726/
https://ncbi.nlm.nih.gov/pubmed/11410677
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