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Item Response Theory to Quantify Longitudinal Placebo and Paliperidone Effects on PANSS Scores in Schizophrenia

As biomarkers are lacking, multi‐item questionnaire‐based tools like the Positive and Negative Syndrome Scale (PANSS) are used to quantify disease severity in schizophrenia. Analyzing composite PANSS scores as continuous data discards information and violates the numerical nature of the scale. Here...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Krekels, EHJ, Novakovic, AM, Vermeulen, AM, Friberg, LE, Karlsson, MO
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572362/
https://ncbi.nlm.nih.gov/pubmed/28571119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12207
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