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Crystal Structure of the C-terminal Domain of Human eIF2D and its Implications on Eukaryotic Translation Initiation

Protein synthesis is a key process in all living organisms. In eukaryotes, Initiation Factor 2 (eIF2) plays an important role in translation initiation as it selects and delivers the initiator tRNA to the small ribosomal subunit. Under stress conditions, phosphorylation of the α-subunit of eIF2 down...

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Publicat a:J Mol Biol
Autors principals: Vaidya, Anand T., Lomakin, Ivan B., Joseph, Newlyn N., Dmitriev, Sergey E., Steitz, Thomas A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572308/
https://ncbi.nlm.nih.gov/pubmed/28736176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.07.015
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