Disseminated tumour cells with highly aberrant genomes are linked to poor prognosis in operable oesophageal adenocarcinoma

BACKGROUND: Chromosomal instability (CIN) has repeatedly been identified as a prognostic marker. Here we evaluated the percentage of aberrant genome per cell (PAG) as a measure of CIN in single disseminated tumour cells (DTC) isolated from patients with operable oesophageal adenocarcinoma (EAC), to...

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Vydáno v:Br J Cancer
Hlavní autoři: Schumacher, Sarah, Bartenhagen, Christoph, Hoffmann, Martin, Will, Daniel, Fischer, Johannes C, Baldus, Stephan E, Vay, Christian, Fluegen, Georg, Dizdar, Levent, Vallböhmer, Daniel, Klein, Christoph A, Knoefel, Wolfram T, Stoecklein, Nikolas H, Möhlendick, Birte
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
Genetics & Genomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572184/
https://ncbi.nlm.nih.gov/pubmed/28728164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.233
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