Protein–ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation

Serial femtosecond crystallography (SFX) with an X-ray free-electron laser is used for the structural determination of proteins from a large number of microcrystals at room temperature. To examine the feasibility of pharmaceutical applications of SFX, a ligand-soaking experiment using thermolysin mi...

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Bibliographic Details
Published in:Acta Crystallogr D Struct Biol
Main Authors: Naitow, Hisashi, Matsuura, Yoshinori, Tono, Kensuke, Joti, Yasumasa, Kameshima, Takashi, Hatsui, Takaki, Yabashi, Makina, Tanaka, Rie, Tanaka, Tomoyuki, Sugahara, Michihiro, Kobayashi, Jun, Nango, Eriko, Iwata, So, Kunishima, Naoki
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2017
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571745/
https://ncbi.nlm.nih.gov/pubmed/28777085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798317008919
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