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Pneumococcal conjugate vaccine induced IgG and nasopharyngeal carriage of pneumococci: Hyporesponsiveness and immune correlates of protection for carriage

BACKGROUND: Prior studies have demonstrated hyporesponsiveness to pneumococcal conjugate vaccines (PCVs) when administered in the presence of homologous carriage. This may be substantially more important in Africa where carriage prevalence is high. Deriving a correlate of protection (CoP) for carria...

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Detalhes bibliográficos
Publicado no:Vaccine
Main Authors: Ojal, John, Hammitt, Laura L., Gaitho, John, Scott, J. Anthony G., Goldblatt, David
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571437/
https://ncbi.nlm.nih.gov/pubmed/28739116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2017.05.088
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