NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma

Tumor-initiating cells (TIC) are dynamic cancer cell subsets that display enhanced tumor functions and resilience to treatment but the mechanism of TIC induction or maintenance in lung cancer is not fully understood. In this study, we show the calcium pathway transcription factor NFATc2 is a novel r...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Xiao, Zhi-Jie, Liu, Jing, Wang, Si-Qi, Zhu, Yun, Gao, Xu-Yuan, Tin, Vicky Pui-Chi, Qin, Jing, Wang, Jun-Wen, Wong, Maria Pik
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Cancer Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570574/
https://ncbi.nlm.nih.gov/pubmed/28737489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26733
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