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Computational investigation of Amyloid-β-induced location- and subunit-specific disturbances of NMDAR at hippocampal dendritic spine in Alzheimer’s disease

In Alzheimer’s disease (AD), dysregulation of intracellular Ca(2+) signalling has been observed as an early event prior to the presence of clinical symptoms and is believed to be a crucial factor contributing to AD pathogenesis. Amyloid-β oligomers (AβOs) disturb the N-methyl-D-aspartate receptor (N...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Liang, Jingyi, Kulasiri, Don, Samarasinghe, Sandhya
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570373/
https://ncbi.nlm.nih.gov/pubmed/28837653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182743
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