A validated LC-MS/MS method for cellular thyroid hormone metabolism: Uptake and turnover of mono-iodinated thyroid hormone metabolites by PCCL3 thyrocytes

Tyrosine and phenolic ring de-iodination of thyroid hormones (TH) is crucial for regulating their physiological activity. Furthermore, reactions such as de-carboxylation to thyronamines (TAM) and de-amination to thyroacetic acids (TAc) produce TH metabolites (THM) with distinct biological properties...

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Bibliographic Details
Published in:PLoS One
Main Authors: Richards, Keith H., Schanze, Nancy, Monk, Ray, Rijntjes, Eddy, Rathmann, Daniel, Köhrle, Josef
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570372/
https://ncbi.nlm.nih.gov/pubmed/28837607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183482
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