Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture

The mechanism of how chronic hepatitis C virus (HCV) infection leads to such a high rate of hepatocellular carcinoma (HCC) is unknown. We found that the PERK axis of endoplasmic reticulum (ER) stress elicited prominent nuclear translocation of Nrf2 in 100% of HCV infected hepatocytes. The sustained...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Aydin, Yucel, Chedid, Milad, Chava, Srinivas, Danielle Williams, Donkita, Liu, Shuanghu, Hagedorn, Curt H., Sumitran-Holgersson, Suchitra, Reiss, Krzysztof, Moroz, Krzysztof, Lu, Hua, Balart, Luis A., Dash, Srikanta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569052/
https://ncbi.nlm.nih.gov/pubmed/28835697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10087-6
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