Hypoxia-sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis

Hypoxia augments inflammatory responses and osteoclastogenesis by incompletely understood mechanisms. We identified COMMD1 as a cell-intrinsic negative regulator of osteoclastogenesis that is suppressed by hypoxia. In human macrophages, COMMD1 restrained induction of NF-κB signaling and a transcript...

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Pubblicato in:Immunity
Autori principali: Murata, Koichi, Fang, Celestia, Terao, Chikashi, Giannopoulou, Eugenia G, Lee, Ye Ji, Lee, Min Joon, Mun, Se-Hwan, Bae, Seyeon, Qiao, Yu, Yuan, Ruoxi, Furu, Moritoshi, Ito, Hiromu, Ohmura, Koichiro, Matsuda, Shuichi, Mimori, Tsuneyo, Matsuda, Fumihiko, Park-Min, Kyung-Hyun, Ivashkiv, Lionel B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568808/
https://ncbi.nlm.nih.gov/pubmed/28723554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.06.018
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