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Membrane-type I Matrix Metalloproteinase-Dependent Ectodomain Shedding of Mucin16/CA-125 on Ovarian Cancer Cells Modulates Adhesion and Invasion of Peritoneal Mesothelium
Mucin16 (MUC16/cancer antigen 125 (CA-125)), a high molecular weight glycoprotein expressed on the ovarian tumor cell surface, potentiates metastasis via selective binding to mesothelin on peritoneal mesothelial cells. Shed MUC16/CA-125 is detectable in sera from ovarian cancer patients. We investig...
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| Publicado no: | Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5568695/ https://ncbi.nlm.nih.gov/pubmed/25205731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/hsz-2014-0155 |
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