Arginase1 deficiency in monocytes/macrophages up-regulates iNOS to promote cutaneous contact hypersensitivity

The innate immune components that modulate allergic contact hypersensitivity (CHS) responses are poorly defined. Using human skin from contact dermatitis patients and a mouse model of CHS, we find that hapten allergens disrupt the Arginase1 (Arg1) and inducible nitric oxide synthase (iNOS or Nos2) d...

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Publicado en:J Immunol
Main Authors: Suwanpradid, Jutamas, Shih, Michael, Pontius, Lauren, Yang, Bin, Birukova, Anastasiya, Guttman-Yasky, Emma, Corcoran, David L., Que, Loretta G., Tighe, Robert M., MacLeod, Amanda S.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568483/
https://ncbi.nlm.nih.gov/pubmed/28747341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700739
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