Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification.

Two-colour in situ hybridization with probes for two co-amplified markers located several megabases apart on chromosome 1 has been used to analyse early stages of adenylate deaminase 2 (AMPD2) gene amplification in Chinese hamster cells. In the amplified chromosomal structures, the distribution of h...

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Bibliografiske detaljer

Udgivet i:	EMBO J
Principais autores:	Toledo, F, Le Roscouet, D, Buttin, G, Debatisse, M
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 1992
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556742/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1628626/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05332.x
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