Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer’s disease progression

Olfactory dysfunction is among the earliest features of Alzheimer’s disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- proteome analysis showed a stage-dependent synaptic proteostasis impairment d...

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Vydáno v:Sci Rep
Hlavní autoři: Lachén-Montes, Mercedes, González-Morales, Andrea, Zelaya, María Victoria, Pérez-Valderrama, Estela, Ausín, Karina, Ferrer, Isidro, Fernández-Irigoyen, Joaquín, Santamaría, Enrique
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567385/
https://ncbi.nlm.nih.gov/pubmed/28831118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09481-x
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