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Unraveling the genetic cause of a consanguineous family with unilateral coloboma and retinoschisis: expanding the phenotypic variability of RAX mutations

Ocular coloboma is a common eye malformation arising from incomplete closure of the human optic fissure during development. Multiple genetic mutations contribute to the disease process, showing extensive genetic heterogeneity and complexity of coloboma spectrum diseases. In this study, we aimed to u...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Huang, Xiu-Feng, Huang, Zhi-Qin, Lin, Dan, Dai, Ma-Li, Wang, Qing-Feng, Chen, Zhen-Ji, Jin, Zi-Bing, Wang, Yuqin
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567291/
https://ncbi.nlm.nih.gov/pubmed/28831107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09276-0
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