Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice

Chronic alcohol feeding causes lipid accumulation and apoptosis in the liver. This study investigated the role of bioactive lipid metabolites in alcohol-induced liver damage and tested the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver disease (ALD). Results...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Zhang, Wenliang, Zhong, Wei, Sun, Qian, Sun, Xinguo, Zhou, Zhanxiang
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567196/
https://ncbi.nlm.nih.gov/pubmed/28827690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02759-0
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