A complex of Neuroplastin and Plasma Membrane Ca(2+) ATPase controls T cell activation

The outcome of T cell activation is determined by mechanisms that balance Ca(2+) influx and clearance. Here we report that murine CD4 T cells lacking Neuroplastin (Nptn (−/−)), an immunoglobulin superfamily protein, display elevated cytosolic Ca(2+) and impaired post-stimulation Ca(2+) clearance, al...

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Publicado no:Sci Rep
Main Authors: Korthals, Mark, Langnaese, Kristina, Smalla, Karl-Heinz, Kähne, Thilo, Herrera-Molina, Rodrigo, Handschuh, Juliane, Lehmann, Anne-Christin, Mamula, Dejan, Naumann, Michael, Seidenbecher, Constanze, Zuschratter, Werner, Tedford, Kerry, Gundelfinger, Eckart D., Montag, Dirk, Fischer, Klaus-Dieter, Thomas, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566957/
https://ncbi.nlm.nih.gov/pubmed/28827723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08519-4
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