Chemotherapy with cisplatin: insights into intracellular pH and metabolic landscape of cancer cells in vitro and in vivo

Although cisplatin plays a central role in cancer chemotherapy, the mechanisms of cell response to this drug have been unexplored. The present study demonstrates the relationships between the intracellular pH (pHi), cell bioenergetics and the response of cervical cancer to cisplatin. pHi was measure...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Shirmanova, Marina V., Druzhkova, Irina N., Lukina, Maria M., Dudenkova, Varvara V., Ignatova, Nadezhda I., Snopova, Ludmila B., Shcheslavskiy, Vladislav I., Belousov, Vsevolod V., Zagaynova, Elena V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566551/
https://ncbi.nlm.nih.gov/pubmed/28827680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09426-4
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