Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation

Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies have shown FG or Geniposide can cause hepatotoxicity in rats. We investigated Genipos...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tian, Jingzhuo, Zhu, Jingjing, Yi, Yan, Li, Chunying, Zhang, Yushi, Zhao, Yong, Pan, Chen, Xiang, Shixie, Li, Xiaolong, Li, Guiqin, Newman, John W, Feng, Xiaoyi, Liu, Jing, Han, Jiayin, Wang, Lianmei, Gao, Yue, La Frano, Michael R., Liang, Aihua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566417/
https://ncbi.nlm.nih.gov/pubmed/28827769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09131-2
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