Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N-cadherin balance in mural cell–endothelial cell-regulated barrier function

The integrity of the endothelial barrier between circulating blood and tissue is important for blood vessel function and, ultimately, for organ homeostasis. Here, we developed a vessel-on-a-chip with perfused endothelialized channels lined with human bone marrow stromal cells, which adopt a mural ce...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Alimperti, Stella, Mirabella, Teodelinda, Bajaj, Varnica, Polacheck, William, Pirone, Dana M., Duffield, Jeremy, Eyckmans, Jeroen, Assoian, Richard K., Chen, Christopher S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2017
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5565405/
https://ncbi.nlm.nih.gov/pubmed/28765370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618333114
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