Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice

RATIONALE: Notch signaling programs cardiac conduction during development, and in the adult ventricle, injury-induced Notch reactivation initiates global transcriptional and epigenetic changes. OBJECTIVE: To determine whether Notch reactivation may stably alter atrial ion channel gene expression and...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Circ Res
Päätekijät: Qiao, Yun, Lipovsky, Catherine, Hicks, Stephanie, Bhatnagar, Somya, Li, Gang, Khandekar, Aditi, Guzy, Robert, Woo, Kel Vin, Nichols, Colin G., Efimov, Igor R., Rentschler, Stacey
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5565396/
https://ncbi.nlm.nih.gov/pubmed/28674041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.310396
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