The apical localization of transcribing RNA polymerases on supercoiled DNA prevents their rotation around the template.

The interaction of Escherichia coli RNA polymerase with supercoiled DNA was visualized by cryo-electron microscopy of vitrified samples and by classical electron microscopy methods. We observed that when E. coli RNA polymerase binds to a promoter on supercoiled DNA, this promoter becomes located at...

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Bibliografische Detailangaben

Veröffentlicht in:	EMBO J
Hauptverfasser:	ten Heggeler-Bordier, B, Wahli, W, Adrian, M, Stasiak, A, Dubochet, J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 1992
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556498/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1537341/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05098.x
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