Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis

Protein tyrosine phosphatase receptor T (PTPRT) is frequently mutated in a variety of human cancers including colorectal cancer. Here we report that PTPRT knockout increases the size of mouse colon tumors in the Apc(min+/−) genetic background, suggesting that inactivation of PTPRT promotes tumor pro...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhao, Yiqing, Scott, Anthony, Zhang, Peng, Hao, Yujun, Feng, Xiujing, Somasundaram, Saigopal, Khalil, Ahmad M., Willis, Joseph, Wang, Zhenghe
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564724/
https://ncbi.nlm.nih.gov/pubmed/27447856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10654
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