Interaction of FUS and HDAC1 Regulates DNA Damage Response and Repair in Neurons

Defects in DNA repair have been extensively linked to neurodegenerative diseases, but the exact mechanisms remain poorly understood. Here, we report that FUS, a RNA/DNA binding protein linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), plays a pivotal role in...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Wang, Wen-Yuan, Pan, Ling, Su, Susan C., Quinn, Emma J., Sasaki, Megumi, Jimenez, Jessica C., Mackenzie, Ian R.A., Huang, Eric J., Tsai, Li-Huei
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564396/
https://ncbi.nlm.nih.gov/pubmed/24036913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3514
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