Interaction of FUS and HDAC1 Regulates DNA Damage Response and Repair in Neurons

Defects in DNA repair have been extensively linked to neurodegenerative diseases, but the exact mechanisms remain poorly understood. Here, we report that FUS, a RNA/DNA binding protein linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), plays a pivotal role in...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Neurosci
Egile Nagusiak: Wang, Wen-Yuan, Pan, Ling, Su, Susan C., Quinn, Emma J., Sasaki, Megumi, Jimenez, Jessica C., Mackenzie, Ian R.A., Huang, Eric J., Tsai, Li-Huei
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564396/
https://ncbi.nlm.nih.gov/pubmed/24036913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3514
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