Lysyl Oxidase Induces Vascular Oxidative Stress and Contributes to Arterial Stiffness and Abnormal Elastin Structure in Hypertension: Role of p38MAPK

Aims: Vascular stiffness, structural elastin abnormalities, and increased oxidative stress are hallmarks of hypertension. Lysyl oxidase (LOX) is an elastin crosslinking enzyme that produces H(2)O(2) as a by-product. We addressed the interplay between LOX, oxidative stress, vessel stiffness, and elas...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Martínez-Revelles, Sonia, García-Redondo, Ana B., Avendaño, María S., Varona, Saray, Palao, Teresa, Orriols, Mar, Roque, Fernanda R., Fortuño, Ana, Touyz, Rhian M., Martínez-González, Jose, Salaices, Mercedes, Rodríguez, Cristina, Briones, Ana M.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563924/
https://ncbi.nlm.nih.gov/pubmed/28010122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2016.6642
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