S-Nitrosoglutathione Reductase Deficiency Confers Improved Survival and Neurological Outcome in Experimental Cerebral Malaria

Artesunate remains the mainstay of treatment for cerebral malaria, but it is less effective in later stages of disease when the host inflammatory response and blood-brain barrier integrity dictate clinical outcomes. Nitric oxide (NO) is an important regulator of inflammation and microvascular integr...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Elphinstone, Robyn E., Besla, Rickvinder, Shikatani, Eric A., Lu, Ziyue, Hausladen, Alfred, Davies, Matthew, Robbins, Clinton S., Husain, Mansoor, Stamler, Jonathan S., Kain, Kevin C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563579/
https://ncbi.nlm.nih.gov/pubmed/28674030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00371-17
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