S-Nitrosoglutathione Reductase Deficiency Confers Improved Survival and Neurological Outcome in Experimental Cerebral Malaria

Artesunate remains the mainstay of treatment for cerebral malaria, but it is less effective in later stages of disease when the host inflammatory response and blood-brain barrier integrity dictate clinical outcomes. Nitric oxide (NO) is an important regulator of inflammation and microvascular integr...

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Опубликовано в: :Infect Immun
Главные авторы: Elphinstone, Robyn E., Besla, Rickvinder, Shikatani, Eric A., Lu, Ziyue, Hausladen, Alfred, Davies, Matthew, Robbins, Clinton S., Husain, Mansoor, Stamler, Jonathan S., Kain, Kevin C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2017
Предметы:
Host Response and Inflammation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563579/
https://ncbi.nlm.nih.gov/pubmed/28674030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00371-17
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