Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin

Hemorrhagic stroke occurs when a weakened vessel ruptures and bleeds into the surrounding brain, leading to high rates of death and disability worldwide. A series of complex pathophysiological cascades contribute to the risk of hemorrhagic stroke, and no therapies have proven effective to prevent he...

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Detalhes bibliográficos
Publicado no:Cell Death Discov
Main Authors: Li, Shang, Ai, Nana, Shen, Mingyun, Dang, Yuanye, Chong, Cheong-Meng, Pan, Peichen, Kwan, Yiu Wa, Chan, Shun Wan, Leung, George Pak Heng, Hoi, Maggie Pui Man, Hou, Tingjun, Lee, Simon Ming-Yuen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563523/
https://ncbi.nlm.nih.gov/pubmed/28845297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2017.51
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