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Directly monitor protein rearrangement on a nanosecond-to-millisecond time-scale
In order to directly observe the refolding kinetics from a partially misfolded state to a native state in the bottom of the protein-folding funnel, we used a “caging” strategy to trap the β-sheet structure of ubiquitin in a misfolded conformation. We used molecular dynamics simulation to generate th...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5562898/ https://ncbi.nlm.nih.gov/pubmed/28821738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08385-0 |
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