Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA–induced dopaminergic denervation

The receptor for advanced glycation endproducts (RAGE) is a pattern-recognition receptor associated with inflammation in most cell types. RAGE up-regulates the expression of proinflammatory mediators and its own expression via activation of NF-kB. Recent works have proposed a role for RAGE in Parkin...

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Publicado en:Sci Rep
Main Authors: Gasparotto, Juciano, Ribeiro, Camila Tiefensee, Bortolin, Rafael Calixto, Somensi, Nauana, Rabelo, Thallita Kelly, Kunzler, Alice, Souza, Natália Cabral, Pasquali, Matheus Augusto de Bittencourt, Moreira, José Claudio Fonseca, Gelain, Daniel Pens
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562811/
https://ncbi.nlm.nih.gov/pubmed/28821831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09257-3
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