Circulating DNA demonstrates convergent evolution and common resistance mechanisms during treatment of colorectal cancer

PURPOSE: Liquid biopsies allow the tracking of clonal dynamics and detection of mutations during treatment. EXPERIMENTAL DESIGN: We evaluated under blinded conditions the ability of cell free DNA (cfDNA) to detect RAS/BRAF mutations in the plasma of 42 metastatic colorectal cancer patients treated o...

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Publié dans:Clin Cancer Res
Auteurs principaux: Thierry, Alain R., Pastor, Brice, Jiang, Zhi-Qin, Katsiampoura, Anastasia D., Parseghian, Christine, Loree, Jonathan M., Overman, Michael J., Sanchez, Cynthia, Messaoudi, Safia El, Ychou, Marc, Kopetz, Scott
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562356/
https://ncbi.nlm.nih.gov/pubmed/28400427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0232
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