Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML290

Relaxin, a small peptide hormone of the insulin/relaxin family, demonstrated antifibrotic, organ protective, vasodilatory, and proangiogenic properties in clinical trials and several animal models of human diseases. Relaxin family peptide receptor 1 (RXFP1) is the relaxin cognate G protein-coupled r...

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Bibliographic Details
Published in:J Endocr Soc
Main Authors: Kaftanovskaya, Elena M., Soula, Mariluz, Myhr, Courtney, Ho, Brian A., Moore, Stefanie N., Yoo, Changwon, Cervantes, Briana, How, Javier, Marugan, Juan, Agoulnik, Irina U., Agoulnik, Alexander I.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2017
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562169/
https://ncbi.nlm.nih.gov/pubmed/28825052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2017-00112
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