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Missense variant pathogenicity predictors generalize well across a range of function-specific prediction challenges

The steady advances in machine learning and accumulation of biomedical data have contributed to the development of numerous computational models that assess the impact of missense variants. Different methods, however, operationalize impact differently. Two common tasks in this context are the predic...

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Vydáno v:Hum Mutat
Hlavní autoři: Pejaver, Vikas, Mooney, Sean D., Radivojac, Predrag
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561458/
https://ncbi.nlm.nih.gov/pubmed/28508593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.23258
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