A randomised, double-blind trial to demonstrate bioequivalence of GP2013 and reference rituximab combined with methotrexate in patients with active rheumatoid arthritis

OBJECTIVES: The aim of this report is to demonstrate pharmacokinetic (PK) and pharmacodynamic (PD) equivalence as well as similar efficacy, safety and immunogenicity between GP2013, a biosimilar rituximab, and innovator rituximab (RTX) in patients with rheumatoid arthritis (RA) with inadequate respo...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Smolen, Josef S, Cohen, Stanley B, Tony, Hans-Peter, Scheinberg, Morton, Kivitz, Alan, Balanescu, Andra, Gomez-Reino, Juan, Cen, Liyi, Zhu, Peijuan, Shisha, Tamas
Formato: Artigo
Idioma:Inglês
Publicado em: Annals of the Rheumatic Diseases 2017
Assuntos:
Clinical and Epidemiological Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561377/
https://ncbi.nlm.nih.gov/pubmed/28637670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2017-211281
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