Targeted blockade of TGF-β and IL-6/JAK2/STAT3 pathways inhibits lung cancer growth promoted by bone marrow-derived myofibroblasts

To investigate the role of TGF-β and IL-6 in myofibroblasts (MFs) — lung cancer cell interactions, lung cancer cells (Lewis and CTM-167 cell lines) were stimulated by IL-6, MF-conditioned medium (MF-CM) or MFs, with or without TGF-β signaling inhibitor — SB431542 and/or JAK2/STAT3 inhibitor — JSI-12...

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Vydáno v:Sci Rep
Hlavní autoři: Shi, Jindong, Feng, Jingjing, Xie, Juan, Mei, Zhoufang, Shi, Tianyun, Wang, Shengmei, Du, Yong, Yang, Gong, Wu, Yougen, Cheng, Xiaojiao, Li, Shanqun, Zhu, Liming, Yang, Chung S., Tu, Shuiping, Jie, Zhijun
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561133/
https://ncbi.nlm.nih.gov/pubmed/28819126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09020-8
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