Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats

BACKGROUND: Studies have demonstrated that resveratrol (a natural polyphenol) and caloric restriction activate Sirtuin-1 (SIRT1) and induce autophagy. Furthermore, autophagy is induced by the SIRT1-FoxO signaling pathway and was recently shown to be a critical protective mechanism against non-alcoho...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ding, Shibin, Jiang, Jinjin, Zhang, Guofu, Bu, Yongjun, Zhang, Guanghui, Zhao, Xiangmei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560739/
https://ncbi.nlm.nih.gov/pubmed/28817690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183541
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