Metformin attenuates myocardial ischemia-reperfusion injury via up-regulation of antioxidant enzymes

The objective was to examine the protective effect of metformin (Met) on myocardial ischemia-reperfusion (IR) injury and whether the mechanism was related to the AMPK/ antioxidant enzymes signaling pathway. Rat Langendorff test and H(2)O(2)-treated rat cardiomyocytes (H9c2) were used in this study....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Wang, Xiaoling, Yang, Lei, Kang, Licheng, Li, Jing, Yang, Liang, Zhang, Jincai, Liu, Jie, Zhu, Mengmeng, Zhang, Qiong, Shen, Yanna, Qi, Zhi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560646/
https://ncbi.nlm.nih.gov/pubmed/28817623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182777
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