The Effect of Alpha-1 Proteinase Inhibitor on Biomarkers of Elastin Degradation in Alpha-1 Antitrypsin Deficiency: An Analysis of the RAPID/RAPID Extension Trials

The RAPID (NCT00261833; N=180) and RAPID Extension (NCT00670007; N=140) trials demonstrated significantly reduced lung density decline in patients with alpha-1 antitrypsin deficiency (AATD) receiving alpha-1 proteinase inhibitor (A1PI) versus placebo. Desmosine and isodesmosine (DES/IDES) are unique...

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Detalhes bibliográficos
Publicado no:Chronic Obstr Pulm Dis
Main Authors: Ma, Shuren, Lin, Yong Y., Cantor, Jerome O., Chapman, Kenneth R., Sandhaus, Robert A., Fries, Michael, Edelman, Jonathan M., McElvaney, Gerard, Turino, Gerard M.
Formato: Artigo
Idioma:Inglês
Publicado em: COPD Foundation Inc 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560248/
https://ncbi.nlm.nih.gov/pubmed/28848909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15326/jcopdf.4.1.2016.0156
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