Preferential Disruption of Prefrontal GABAergic Function by Nanomolar Concentrations of the α7nACh Negative Modulator Kynurenic Acid

Increased concentrations of kynurenic acid (KYNA) in the prefrontal cortex (PFC) are thought to contribute to the development of cognitive deficits observed in schizophrenia. Although this view is consistent with preclinical studies showing a negative impact of prefrontal KYNA elevation on executive...

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Publicat a:J Neurosci
Autors principals: Flores-Barrera, Eden, Thomases, Daniel R., Cass, Daryn K., Bhandari, Ajay, Schwarcz, Robert, Bruno, John P., Tseng, Kuei Y.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559765/
https://ncbi.nlm.nih.gov/pubmed/28729445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0932-17.2017
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