PIK3CA mutations contribute to acquired cetuximab resistance in metastatic colorectal cancer patients

PURPOSE: Mutations in KRAS are considered to be the main drivers of acquired resistance to epidermal growth factor receptor (EGFR) blockade in patients with metastatic colorectal cancer (mCRC). However, the potential roles of other genes downstream of the EGFR signaling pathway in conferring acquire...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Xu, Jian-Ming, Wang, Yan, Wang, You-Liang, Liu, Tao, Ni, Ming, Li, Man-Sheng, Lin, Li, Ge, Fei-Jiao, Gong, Chun, Gu, Jun-Yan, Jia, Ru, Wang, He-Fei, Chen, Yu-Ling, Liu, Rong-Rui, Zhao, Chuan-Hua, Tan, Zhao-Li, Jin, Yang, Zhu, Yun-Ping, Ogino, Shuji, Qian, Zhi-Rong
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559326/
https://ncbi.nlm.nih.gov/pubmed/28424201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2738
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