Heritability Estimation using a Regularized Regression Approach (HERRA): Applicable to continuous, dichotomous or age-at-onset outcome

The popular Genome-wide Complex Trait Analysis (GCTA) software uses the random-effects models for estimating the narrow-sense heritability based on GWAS data of unrelated individuals without knowing and identifying the causal loci. Many methods have since extended this approach to various situations...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gorfine, Malka, Berndt, Sonja I., Chang-Claude, Jenny, Hoffmeister, Michael, Le Marchand, Loic, Potter, John, Slattery, Martha L., Keret, Nir, Peters, Ulrike, Hsu, Li
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559077/
https://ncbi.nlm.nih.gov/pubmed/28813438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181269
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