BACE inhibition-dependent repair of Alzheimer’s pathophysiology

Amyloid-β (Aβ) is thought to play an essential pathogenic role in Alzheimer´s disease (AD). A key enzyme involved in the generation of Aβ is the β-secretase BACE, for which powerful inhibitors have been developed and are currently in use in human clinical trials. However, although BACE inhibition ca...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Keskin, Aylin D., Kekuš, Maja, Adelsberger, Helmuth, Neumann, Ulf, Shimshek, Derya R., Song, Beomjong, Zott, Benedikt, Peng, Tingying, Förstl, Hans, Staufenbiel, Matthias, Nelken, Israel, Sakmann, Bert, Konnerth, Arthur, Busche, Marc Aurel
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2017
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559049/
https://ncbi.nlm.nih.gov/pubmed/28739891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708106114
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