BACE inhibition-dependent repair of Alzheimer’s pathophysiology

Amyloid-β (Aβ) is thought to play an essential pathogenic role in Alzheimer´s disease (AD). A key enzyme involved in the generation of Aβ is the β-secretase BACE, for which powerful inhibitors have been developed and are currently in use in human clinical trials. However, although BACE inhibition ca...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Keskin, Aylin D., Kekuš, Maja, Adelsberger, Helmuth, Neumann, Ulf, Shimshek, Derya R., Song, Beomjong, Zott, Benedikt, Peng, Tingying, Förstl, Hans, Staufenbiel, Matthias, Nelken, Israel, Sakmann, Bert, Konnerth, Arthur, Busche, Marc Aurel
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2017
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559049/
https://ncbi.nlm.nih.gov/pubmed/28739891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708106114
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