BACE inhibition-dependent repair of Alzheimer’s pathophysiology

Amyloid-β (Aβ) is thought to play an essential pathogenic role in Alzheimer´s disease (AD). A key enzyme involved in the generation of Aβ is the β-secretase BACE, for which powerful inhibitors have been developed and are currently in use in human clinical trials. However, although BACE inhibition ca...

詳細記述

保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Keskin, Aylin D., Kekuš, Maja, Adelsberger, Helmuth, Neumann, Ulf, Shimshek, Derya R., Song, Beomjong, Zott, Benedikt, Peng, Tingying, Förstl, Hans, Staufenbiel, Matthias, Nelken, Israel, Sakmann, Bert, Konnerth, Arthur, Busche, Marc Aurel
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2017
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559049/
https://ncbi.nlm.nih.gov/pubmed/28739891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708106114
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